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Originally Posted by: Dartagnan  24.12.2011 by emily Category Electromagnetic Health Blog Press ReleaseBrain Tumor Pandemic—DNA Impacts from Mobile Phones Implicated in New Analysis December 24, 2011, Berkeley, CA, USA & Stockholm, Sweden. An important new analysis, The Potential Impact of Mobile Phone Use on Trends in Brain and CNS Tumors, was published today in the journal Neurology & Neurophysiology. It can be downloaded without cost athttp://www.omicsonline.o...562/2155-9562-S5-003.pdf. The paper is in a Special Issue of the journal titled “Brain Tumor.” The study raises very serious concerns about the potential for a large increase in brain cancer incidence, resulting from widespread mobile phone use. The steep increase in brain cancer will begin in approximately 15 years according to the projections. The paper, by researchers Örjan Hallberg in Sweden and L. Lloyd Morgan in the U.S., first reviews biological effects from mobile phone use reported in peer-reviewed studies, such as increased permeability of the blood-brain barrier, deleterious effects on sperm, double strand breaks in DNA, stress gene activation (indicating an exposure to a toxin), and increased risk of an acoustic nerve tumor (acoustic neuroma) and brain cancer after 10 or more years of mobile phone use. It then considered two established mechanisms for the development of brain cancer—that mobile phone use decreases the efficiency of the repair of mutated DNA and that mobile phone use increases the rate of DNA mutations. In developing the model from brain cancer registry data, mathematical model parameters are selected which provide a best fit to the age adjusted registry data. The model can be considered reasonably accurate if it approximates both the age-specific brain cancer incidence (e.g., 30-34 year age cohort) and the age-adjusted brain cancer incidence from the cancer registry data. It can then be used by the researchers to predict future brain cancer incidence. Based on a 30-year time between first mobile phone use and diagnoses of brain cancer (latency time), the model predicts that there will be a 100% increased incidence of brain cancer (2-fold) if DNA repair efficiency is decreased by mobile phone use, and a 2,400% increase in brain tumors (25-fold) if mobile phone use mutates DNA. The figure below, from the paper illustrates these predictions. Figure 3. Norwegian brain tumor age-adjusted rates per 100,000 person-years by calendar year for reported data with 3 results from mobile phone use 1) Increased DNA damage 2) no DNA repair and 3) has no effect. The public health risk modeling process used in this analysis was developed by Örjan Hallberg and has been successfully applied in other illnesses, including Alzheimer’s disease and melanoma. Hallberg says, “Such modeling, or risk projection, is important, whether for the climate or for diseases, in that it allows public health contingency planning, should the model be reasonable accurate. For example, will there be sufficient neurosurgeons should brain tumors increase as the model predicts?” Morgan says, “What this analysis shows is that, unless mobile phone usage behavior patterns change significantly, we can reasonably expect a pandemic of brain tumors, for which we are ill-prepared, beginning approximately 15 years from now. Governments, as well as parents, physicians, schools and all citizens, would be well advised to educate all persons under their care or influence about the need to curtail the use of mobile phones and other radiation-emitting consumer devices.” Media Contacts: Europe: Örjan Hallberg in Sweden (oerjan.hallberg@tele2.se, + 46 (8) 605 4998). North America: Lloyd Morgan in Berkeley, California, USA Sr. Research Fellow, Environmental Health Trust (Lloyd.L.Morgan@gmail.com, +510 841-4362). http://electromagnetiche...-tumor-pandemic/?mid=560 New Paper: EMF effects on mouse brain proteomeJanuary 21, 2012 in -Mailing List, Cell phone news by EMFacts Press release: January 25, 2012 The research group of Professor Lukas Margaritis (Faculty of Biology, University of Athens and the Biomedical Research Foundation of the Academy of Athens), within the framework of the activities seeking for the truth underlining the possible effects of daily life electromagnetic fields, has performed this study as part of the Doctorate Dissertation of Adamantia F. Fragopoulou. Using ordinary working conditions of mobile phone and wireless DECT base and by applying state of the art proteome science approaches, they demonstrated that a large number of major brain proteins have been changed. Namely proteins that are responsible for the integrity of brain functions, in such critical regions like hippocampus, cerebellum and frontal lobe are below normal levels whereas an equally large number are found well above physiological levels. These “underexpressed” or “overexressed” proteins may play a role in the short term or long term effects reported as a consequence of mobile phone exposure, including memory deficits, headaches, sleep disorders, brain tumors. This study is the first large scale analysis of the mouse brain proteome to be published so far. The research team having recently been awarded a large “Thalis” grant is potentially aiming in elucidating the EMF effects from the molecular level up to the organism level, exploiting the most suitable model systems (mice, insects, nematodes, lizards, cell cultures, human skin). Published in Electromagnetic Biology and Medicine, Early Online: 1–25, 2012 Copyright Q Informa Healthcare USA, Inc. Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation Adamantia F. Fragopoulou1, Athina Samara2, Marianna H. Antonelou1, Anta Xanthopoulou3, Aggeliki Papadopoulou3, Konstantinos Vougas3, Eugenia Koutsogiannopoulou2, Ema Anastasiadou2, Dimitrios J. Stravopodis1, George Th. Tsangaris3 & Lukas H. Margaritis1 1Department of Cell Biology and Biophysics, Athens University, Athens, Greece, 2Genetics and Gene Therapy Division, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece, and 3Proteomics Research Unit, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece Abstract: The objective of this study was to investigate the effects of two sources of electromagnetic fields (EMFs) on the proteome of cerebellum, hippocampus, and frontal lobe in Balb/c mice following long-term whole body irradiation. Three equally divided groups of animals (6 animals/group) were used; the first group was exposed to a typical mobile phone, at a SAR level range of 0.17– 0.37 W/kg for 3 h daily for 8 months, the second group was exposed to a wireless DECT base (Digital Enhanced Cordless Telecommunications/Telephone) at a SAR level range of 0.012– 0.028 W/kg for 8 h/day also for 8 months and the third group comprised the sham-exposed animals. Comparative proteomics analysis revealed that long-term irradiation from both EMF sources altered significantly (p , 0.05) the expression of 143 proteins in total (as low as 0.003 fold downregulation up to 114 fold overexpression). Several neural function related proteins (i.e., Glial Fibrillary Acidic Protein (GFAP), Alpha-synuclein, Glia Maturation Factor beta (GMF), and apolipoprotein E (apoE)), heat shock proteins, and cytoskeletal proteins (i.e., Neurofilaments and tropomodulin) are included in this list as well as proteins of the brain metabolism (i.e., Aspartate aminotransferase, Glutamate dehydrogenase) to nearly all brain regions studied. Western blot analysis on selected proteins confirmed the proteomics data. The observed protein expression changes may be related to brain plasticity alterations, indicative of oxidative stress in the nervous system or involved in apoptosis and might potentially explain human health hazards reported so far, such as headaches, sleep disturbance, fatigue, memory deficits, and brain tumor long-term induction under similar exposure conditions. Read the full story here. "I'd love to open a tennis school for children in my hometown of Sochi." said Sharapova Maria.
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